| Item Type | Name |
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Concept
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Drug Resistance
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Concept
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Drug Resistance, Neoplasm
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Concept
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Drug Resistance, Multiple
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Academic Article
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Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents.
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Academic Article
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Silence is golden: gene hypermethylation and survival in large-cell lymphoma.
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Academic Article
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A phase II trial of oral temozolomide in patients with metastatic renal cell cancer.
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Academic Article
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Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
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Academic Article
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Temozolomide: realizing the promise and potential.
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Academic Article
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Molecular mechanisms of resistance and toxicity associated with platinating agents.
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Academic Article
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Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity.
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Academic Article
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Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy.
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Academic Article
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Genetic variants contributing to daunorubicin-induced cytotoxicity.
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Academic Article
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Role of copper transporters in resistance to platinating agents.
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Academic Article
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Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity.
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Academic Article
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Whole-genome approach implicates CD44 in cellular resistance to carboplatin.
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Academic Article
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Cancer pharmacoethnicity: ethnic differences in susceptibility to the effects of chemotherapy.
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Academic Article
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PACdb: a database for cell-based pharmacogenomics.
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Academic Article
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Comprehensive evaluation of the contribution of X chromosome genes to platinum sensitivity.
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Academic Article
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Susceptibility loci involved in cisplatin-induced cytotoxicity and apoptosis.
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Academic Article
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Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.
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Academic Article
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Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.
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Academic Article
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Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans.
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Academic Article
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Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
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Academic Article
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Correlation between O6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitrosoguanidine.
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Academic Article
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Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
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Academic Article
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The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells.
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Academic Article
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Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
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Academic Article
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Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study.
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Academic Article
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Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
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Academic Article
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Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.
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Academic Article
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Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
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Academic Article
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Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations.
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Academic Article
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Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients.
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Academic Article
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MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.
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Academic Article
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Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
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Academic Article
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Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
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Academic Article
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Mechanisms of resistance to the toxicity of cyclophosphamide.
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Academic Article
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Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.
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Academic Article
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The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.
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Academic Article
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Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients.
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Academic Article
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Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach.
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Academic Article
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Gene and MicroRNA Perturbations of Cellular Response to Pemetrexed Implicate Biological Networks and Enable Imputation of Response in Lung Adenocarcinoma.
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Academic Article
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Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.
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